658425
AG 17
NSC 242557, 3,5-di-t-Butyl-4-hydroxy-benzylidenemalononitrile, α-Cyano-(3,5-di-t-butyl-4-hydroxy)cinnamonitrile, Tyrphostin A9, RG 50872
For general questions please contact our Customer Service:
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Phone: +49 6151 72-0
Fax: +49 6151 72 2000
04 February 2012
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Anti-proliferative agent that acts as a selective inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC50 = 500 nM). A potent, cell-permeable, reversible, and substrate competitive inhibitor of TNF-induced tyrosine phosphorylation of PYK2. Uncouples oxidative phosphorylation and induces apoptosis and cell growth arrest in NHL cell lines. Inhibits Cdk2 activity in lymphoma cell lines.
| Product information | |||
|---|---|---|---|
| Form | Pale yellow solid | ||
| Primary Target | platelet-derived growth factor receptor tyrosine kinase | ||
| Primary Target IC50 | 500 nM | ||
| Secondary target | induced tyrosine phosphorylation of PYK2 | ||
| Molar mass | 282.4 | ||
| Protect from Light | Yes | ||
| Purity | ≥99% by TLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C18H22N2O | ||
| RTECS | OO3737000 | ||
| CAS number | 10537-47-0 | ||
| Store and ship information | |||
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Toxic |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 36/37/39-45 Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
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| R Phrase |
R: 23/24/25 Toxic by inhalation, in contact with skin and if swallowed. |
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